Endocrine Abstracts

GH deficiency (GHD) in adults is characterized by a tendency towards fat mass gain and may predispose to type 2 diabetes mellitus.GH replacement (GHR) is associated with impaired insulin sensitivity shortly after starting therapy, reflected by increased fasting glucose and insulin levels. Available evidence suggests that concerns regarding glucose intolerance in patients receiving long-term GHR have not been substantiated. However, several environmental and lifestyle-related f...

Introduction and aim: The current population is experiencing an increase in life expectancy, with a consequent change in the demographic structure of the society. It is common, therefore, to find elderly patients with pituitary neuroendocrine tumors (PitNET) in our usual clinical practice. Currently, there are no specific recommendations for treatment and data of outcomes in elderly are scarce. The aim of our study was to compare the clinical characteristics and surgical outco...

Purpose: To evaluate the prevalence of autonomous cortisol secretion (ACS) in patients with primary aldosteronism (PA) and its implications on cardiometabolic and surgical outcomes.Methods: A retrospective multicenter study of PA patients who underwent 1mg-dexamethasone suppression test (DST) in follow-up in 21 Spanish tertiary hospitals. ACS was defined as a cortisol post-DST >1.8μg/dL (confirmed ACS if >5μg/dL and possible ACS if between 1.8-...